Unique Original Articles » Neurons that lead to overeating, also push a hunger for cocaine

Neurons that lead to overeating, also push a hunger for cocaine

Author: RehabWiz

Recently published research from the Yale School of Medicine pinpointed an area of the brain responsible for controlling hunger. Interestingly enough, that same region is also responsible for driving non-food related behavior like novelty-seeking and drug addiction.

Nature Neuroscience published the study, conducted by postdoctoral associate Marcelo O. Dietrich and his colleagues Tamas L. Horvath and David W. Wallace, both professors of Biomedical Research at Yale School of Medicine.

The brain’s pleasure circuits, located in the midbrain have come under increased scrutiny by neuroscientists looking to make sense of metabolic issues like diabetes and obesity, as well as potential applications for substance abuse.

“We found that increased appetite for food can actually be associated with decreased interest in novelty as well as in cocaine, and on the other hand less interest in food can predict increased interest in cocaine,” said Dietrich.

Transgenic mice, that had their genome modified for academic purposes, were studied by Horvath and his team. One set had a signaling molecule replaced that controls hunger-promoting neurons in the hypothalamus. The other set had their neurons manipulated selectively during development using diphtheria toxin. Non-invasive tests were then administered to measure how the mice responded to novelty, anxiety, and cocaine.

“We found that animals that have less interest in food are more interested in novelty-seeking behaviors and drugs like cocaine,” said Horvath. “This suggests that there may be individuals with increased drive of the reward circuitry, but who are still leaning. This is a complex trait that arises from the activity of the basic feeding circuits during development, which then impacts the adult response to drugs and novelty in the environment.”

Horvath and his colleagues demonstrated that the hypothalamus, which controls vital functions like body temperature, hunger, fatigue, thirst, and sleep, is crucial to developing higher brain function. Potential benefits for addiction treatment centers., around the world are likely to result from this unique research.

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